Antibiotic Alternatives

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Retrieved: September 21, 2019, 4:09 am

This article written by Dr. Reynold Bergen, BCRC Science Director, originally appeared in the October 2016 issue of Canadian Cattlemen magazine and is reprinted on the BCRC Blog with permission of the publisher.


AntibioticCCM
Antibiotics are a tremendously valuable tool in livestock production. For example, at this time of year, groups of light-weight, freshly weaned, shrunk-out calves with an unknown vaccination or nutritional history arriving at a feedlot after being transported long distances from pre-sort sales in cool, wet fall weather are likely candidates for bovine respiratory disease (BRD). Treating these calves with a preventative antibiotic (metaphylaxis) after they arrive at the feedlot can greatly reduce health problems, suffering and death losses in these calves during their first few weeks on feed.

Bacteria will develop resistance to antibiotics that are used routinely on the ranch or in the feedlot, so these antibiotics will become less effective for preventing or treating disease. This doesn’t directly translate to a concern about antibiotic resistant bacteria in retail beef.
In fact, antibiotic resistance surveillance has repeatedly shown that levels of antibiotic resistant bacteria in Canada’s retail beef is enviably low, indicating consumers aren’t at risk from antibiotic resistance and use in beef production. However, global concerns about the declining effectiveness of antimicrobials in human medicine have led many countries, including Canada, to take another look at how medically important antibiotics (i.e. all antibiotics other than ionophores like Rumensin, Bovatec and Posistac) are used in livestock production. A number of regulatory and policy changes are being implemented that will make a number of livestock antimicrobials less accessible, less convenient, and potentially less affordable to use in the near future. This will present both challenges and opportunities to all livestock industries. One big challenge is obvious – animal health may have to be managed differently. A big opportunity may be to finally take advantage of knowledge that the beef industry has had for a long time.

Now for a hard left.

Like all animals, cattle are full of bacteria and other microbes; this is called the microbiome. The microbiome is very complex, and most of the functions and inter-relationships among these microbes are a complete mystery to science. Most members of the microbiome are probably harmless or maybe even beneficial. Even some disease causing (pathogenic) bacteria can be present in the microbiome without causing problems. An example is Mannheimia haemolytica, which is often found in the noses of healthy cattle. The animal will stay healthy as long as Mannheimia stays in the nose. But if stress causes the microbiome to be disrupted, Mannheimia can move deeper into the lung and contribute to bovine respiratory disease.

So now we have a stressed calf that is likely to develop BRD (probably one of the ones described in the second sentence at the start of this column), and it gets a shot to prevent or treat the disease. If the right antibiotic is used, it will probably kill the Mannheimia. But most antibiotics are actually pretty blunt weapons. Antibiotics aren’t like a sniper that only eliminates the specific pathogen that it’s sent in to kill. An antibiotic is more like a grenade that kills or injures the pathogen, as well as any other potentially susceptible bacteria that it happens to come into contact with it. So although antibiotics are effective at combatting disease, they can also disrupt the microbiome. Then the microbiome has to knit itself back together and resume it’s normal functioning before the animal has fully recovered.

Finding ways to avoid disrupting the microbiome may be key to maintaining animal health. Antibiotic alternatives may allow disease to be prevented or treated in a much more targeted manner, without disrupting the microbiome, and this may have benefits for animal health.

Broadly speaking, there are two kinds of antimicrobial alternatives. One is a large collection of things like immunomodulators to boost the immune system, probiotics (healthy microbes to strengthen the microbiome), prebiotics (nutrients to support beneficial bacteria in the microbiome), viruses to attack pathogenic bacteria, essential oils, tannins, phenolics, seaweed extracts, citrus products, organic acids, bacteriocins and various other products. So far, these products have had inconsistent effectiveness. They may work better in the future, but at this point they need further research and development.

Other alternatives include a number of management practices that we can implement today, and are known to reduce the incidence of BRD. These include practices like a good nutrition program on the ranch, working with your veterinarian to develop and implement an effective vaccination program for your herd, adopting low-stress weaning if labor and facilities allow, and avoiding commingling as much as possible.

Breaking up all those stressors listed in the second sentence so that they don’t all happen within a five-day period should help calves maintain a healthy microbiome that can resist BRD. We will likely never be able to eliminate all antimicrobials from cattle production. But market demand for “reputation cattle” will likely strengthen as antimicrobials become less accessible and convenient.

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2 thoughts on “Antibiotic Alternatives

  1. Dear Sir or Madam:
    This first part of the article caught my eye. It also raised some questions.
    “For example, at this time of year, groups of light-weight, freshly weaned, shrunk-out calves with an unknown vaccination or nutritional history arriving at a feedlot after being transported long distances from pre-sort sales in cool, wet fall weather are likely candidates for bovine respiratory disease (BRD).”

    The obvious answers, which the author addressed at the end of the blog, include these: 1)make sure the calves are well-fleshed, not freshly weaned, and certainly not shrunk-out. 2)Don’t accept calves with unknown vaccination or nutritional history; 3)Don’t send calves long distances from pre-sort sales in cool, wet fall weather.

    As I said, the author does address these things at the end of the article. I would like to see some brave soul address the centralization of the abbatoir situation/meat-packing industry in Canada which would do a lot to help prevent the problems mentioned. I also wonder how all the recent affirmation about animal welfare in our Canadian beef industry is to have any credibility if we are sending freshly weaned, shrunk-out, poorly fleshed calves long distances in cool, fall weather.

    Something is not right here.

    Sincerely,
    Curt Gesch

  2. Hi Curt

    I think that narrow margins, economies of scale and geographical differences in feeding costs mean that centralization and consolidation will continue to be a factor in open markets, at least as long as purchasing decisions are impacted by prices. We’re certainly seeing more consumer interest in agricultural production practices now; whether that concern will be accompanied by a widespread willingness to pay more when production costs go up is less clear. So while it might be nice to have smaller feedlots and packing plants scattered all over the countryside, that’s probably not a very realistic expectation.

    There has definitely been consolidation in Canada’s feeding and packing sectors, with fewer, larger operations predominating. But we’ve also seen considerable evolution in industry structure and cattle transport practices over the years. In the late 1800’s, Canada literally shipped live feeder and slaughter cattle overseas to Britain for finishing and packing. Later, large numbers of Canadian feeder cattle were railed from western to central Canada or into the Midwest US for finishing or slaughter. Less trans-continental transport occurs now that there are well-established feeding and processing sectors in both western and eastern Canada, and highway transport allows much more rapid long-distance transport than trains ever did. I can’t prove this, but I suspect that today’s transport health and welfare outcomes are likely much better for Canadian beef calves today than they would have been 50 years ago.

    Recent years have also seen considerable consolidation on the cow-calf side. Operations with larger herds are in a much stronger position to benefit from marketing large groups of reputation calves than the much smaller herds that were typical back in the 1980’s when green-tag sales promoted preconditioned calves. We continue to see the development of new and improved ways to reduce the risks to calf health, through attention to nutrition, appropriate vaccination, low-stress weaning, avoiding commingling, hiring reputable transporters, frequent pen checking, early disease detection and prompt and appropriate treatment, as recommended and/or required in Canada’s Code of Practice for the Care and Handling of Beef Cattle. These Code requirements have now been incorporated into the Verified Beef Production program (along with on-farm food safety, biosecurity and environment modules). The VBP Plus program provides an auditable, practical, affordable, effective way for producers to demonstrate that they are following sustainable beef production practices. It also provides a convenient way for packers, retailers and consumers to source cattle and beef that has been raised in a sustainable manner.

    Canada’s beef industry has made and continues to make improvements to the way we raise cattle and beef. There will always be things we can do, and we will find ways to do better, but we can still be proud of the improvements we’ve made. That’s particularly true with programs like Quality Starts Here / Verified Beef Production, that anticipated some of these societal changes two decades before the packing and retail sectors were starting to ask for it.

    I hope this answers your questions.

    Reynold

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